Chloramphenicol injection fda prescribing information, side. Despite being highly effective, it shows severe toxicity in. Chloramphenicol is a known respiratory sensitizer and known skin sensitiser. This material safety data sheet does not constitute the guaranty or specifications of the product. Chloramphenicol may cause gray syndrome and serious, fatal blood dyscrasias. Serious and fatal blood effects aplastic anemia, hypoplastic. It is often used for bacterial selection in molecular biology applications at 1020. Product identifier product name chloramphenicol product number ac09460. Dthreo2,2dichloronbetahydroxyalphahydroxymethylpnitrophenylethylacetamid e recommended use laboratory chemicals. For the isolation of yeast and molds associated with spoilage, add oxoid chloramphenicol selective supplement to drbc agar base, part no.
Weve included the most sought after safety data sheets, and the database just keeps growing. No ecological problems are to be expected when the product is handled and used with due care and attention. Material safety data sheet section 1product identification and use product identifier chloramphenicol supplement catalogue number. Only select registry of toxic effects of chemical substances rtecs data is presented here. Sensitivity testing is essential to determine its indicated use, but may be performed concurrently with therapy. In vitro, chloramphenicol exerts mainly a bacteriostatic effect on a wide range of gramnegative and grampositive bacteria. Chloramphenicol chemicals biochemicals antibiotics. Download msds pdf search msds currently available for download. See actual entry in rtecs for complete information. Chloramphenicol suppliermanufacturer 3420 central expressway, santa clara ca 95051 in case of emergency chemtrec. Sds of chloramphenicol, safety data sheets, cas 56757. Chloramphenicol is prohibited from use in foodproducing animals by the canadian health protection branch. Section 1 chemical product and company identification.
Chloramphenicol sodium succinate must be hydrolyzed to its microbiologically active form, and there is a lag in achieving adequate blood levels compared with the base given intravenously. Safecoat flat pastel base zero voc suspected cancer agents product i. Because of hepatic metabolism, active chloramphenicol does not accumulate when renal insufficiency is present. It involves abdominal distention, pallid cyanosis, and vasomotor collapse leading to death. Full text full text is available as a scanned copy of the original print version. Chloramphenicol ophthalmic ointment 1% revision date. Chloramphenicol is distributed widely in body fluids, including csf, and is excreted in urine. Quantitative and qualitative composition chlorsig eye drops. H351 90 100 % for the full text of the hstatements mentioned in this section, see section 16. Its use by mouth or by injection is only recommended when safer antibiotics cannot be used. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910.
Dailymed chloramphenicol sodium succinate chloramphenicol. Based on available data for the ingredients, the mixture has a classification of germ cell mutagenicity category 1b. The infected eye will probably be red, gritty or itchy. Chloramphenicol palmitate chloramphenicole palmitas article number. Safety data sheet according to 19072006 eec article 31 38.
Dec 01, 2019 chloramphenicol is a broadspectrum antibiotic originally isolated from streptomyces venezuelae. Leukaemia risk may be increased following chloramphenicol use, according to one study which depended on parental recall during interviews. This may cause more chance of getting an infection, bleeding problems, or slow healing. Recommended use laboratory chemicals emergency telephone number carechem 24. Aplastic anemia that happened with chloramphenicol has led to.
Blood dyscrasias are reductions in blood cells leading to aplastic anemia, thrombocytopenia, and granulocytopenia. Quantitative data on the toxicity of this product is not available. R454462 risk phrases safety phrases ec classification not classified. Emergency phone no 5173729200 740 east shiawassee fax no 5173720108 lansing, michigan 48912 email. Despite being highly effective, it shows severe toxicity in the form of aplastic anemia aa and.
Safety data sheet 103290 chloramphenicol succinate sodium salt. Our msds database is an easy to use, do it yourself tool, and best of all. Company identification and product information product name or identity. Chloramphenicol was introduced into medical practice in 1949.
Very bad and sometimes deadly blood problems have happened with chloramphenicol. The binding interferes with peptidyl transferase activity, thereby prevents transfer of. These can be read online or downloaded to be read in the future. Safety data sheet california carb compliant 1 identification product name. To enable you to view and print pdf files, you will need adobe reader installed on your computer. Download msds pdf search msds currently available for download bioworld offers chloramphenicol for your research at low price. Accidental release measures contain spill and collect, as appropriate. Patients started on intravenous chloramphenicol sodium succinate should be changed to the oral form of another appropriate antibiotic as soon as practicable. View or download the chloramphenicol cas 56757 calbiochem msds material safety data sheet or sds for 220551 from milliporesigma. Safety data sheet northwest missouri state university. Chloramphenicol inhibits protein synthesis by preventing peptide bond formation by peptidyl transferase.
Links to pubmed are also available for selected references. Prevent entry into sewers, water courses, basements or confined areas. Must be equipped with self contained breathing apparatus. Chloramphenicol is usedin both adults and children to treat bacterial conjunctivitis, which is an infection of the outer surfaces of the eye.
Page 3 of 5 7 handling and storage precautions for safe handling. Chloramphenicol is a semisynthetic, broadspectrum antibiotic derived from streptomyces venequelae with primarily bacteriostatic activity. Remel prepared culture media containing chloramphenicol and cycloheximide version. Chloramphenicol has been used as a bacteriostatic non potent antibiotic. Chloramphenicol is available under the following different brand names. Lc55 manufacturers name suppliers name dalynn biologicals inc.
Material safety data sheet prepared according to 29 cfr 1910. Sweep or vacuum material and place in a designated waste container. Within the cell, it binds to the 50s subunit of bacterial ribosomes and inhibits bacterial protein synthesis by preventing attachment of aminoacyl transfer rna to its acceptor site on the ribosome, thus preventing peptide bond formation by peptidyl transferase. Commission regulation eu no 2015830 of 28 may 2015. Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50s ribosomal subunit. Sabouraud dextrose agar w chloramphenicol manufacturers name. Buy and get information for chloramphenicol, cms218, 56757, chemicals, biochemicals, antibiotics. Chloramphenicol was found to be effective against typhus in 1948 and became the first antibiotic to undergo largescale production.
A registration number is not available for this substance as the substance or its uses are exempted from registration, the. Chloramphenicol is a synthetic antibiotic, isolated from strains of streptomyces venezuelae. Lab119 yeast extract dextrose chloramphenicol agar issue. Dec 31, 2019 chloramphenicol sodium succinate must be hydrolyzed to its microbiologically active form, and there is a lag in achieving adequate blood levels compared with the base given intravenously. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Bacteriostatic agent against gramnegative and grampositive bacteria. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. In the morning there will be a sticky discharge which may make it difficult to open the eye. The binding interferes with peptidyl transferase activity. Lubricant, penetrant, drives out moisture, removes and protects surfaces from corrosion restrictions on use. In case of doubt or when symptoms of feeling unwell persist, get medical attention. This includes use as an eye ointment to treat conjunctivitis. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever.
Safety data sheet chlorocresol msds catalog service llc. Chloramphenicol sodium succinate chloramphenicol sodium. Chloramphenicol has been classified by the iarc as group 2a. Chloramphenicol injection fda prescribing information. Identification of the substancemixture and of the companyundertaking 1. Accidental release measures environmental precautions personal precautions, protective equipment and emergency procedures move containers from spill area. Chloramphenicol is an antibiotic that is clinically useful for, and should be reserved for, serious infections caused by organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. At therapeutic concentrations of 10 to 20 micrograms drug per ml, the drug inhibits bacterial ribosomal and, to a lesser extent, mammalian mitochondrial protein synthesis but concentrations above 60 micrograms drug. Safety data sheet chloramphenicol according to regulation ec no 19072006, annex ii, as amended. Sabouraud dextrose agar safety data sheet date of issue 03122008.
Chloramphenicol cap is a potent and efficient antibiotic used since years against many pathogens. Gray syndrome occurs in premature infants and neonates. Get a printable copy pdf file of the complete article 1. Hazards identification respiratory sensitization category 1 skin sensitization category 1 carcinogenicity category 1b. Remel prepared culture media containing chloramphenicol and cycloheximide catalog numbers.
Everolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the hydroxy group with a silylprotected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. H350 90 100 % for the full text of the h statements mentioned in this section, see section 16. Chloramphenicol sodium succinate for injection, usp fresenius kabi usa, llc revision. Chloramphenicol tablets usp are labeled for veterinary use only. Chloramphenicol is prescription intravenous antibiotic for treatment of serious infections and systemic infections. Based on available data for the ingredients, the mixture.
Use of chloramphenicol during pregnancy results in fetal drug levels almost as high as maternal levels. Wear disposable gloves, eye protection, dust mas k and protective clothing. Chloramphenicol investigated as an agricultural chemical, drug, mutagen, natural product, reproductive effector, and tumorigen. Chloramphenicol product number c 7795 storage temperature 28 c product description molecular formula. This can be downloaded from the adobe web site by clicking here or on the get adobe reader icon below. Product name chloramphenicol selective supplement cat no.
It inhibits bacterial protein synthesis by interfering with the transfer of activated amino acids from soluble rna to ribosomes. Documents on the oxoid web site are sometimes held in pdf format. Safety during breastfeeding has not been determined. Hazards identification the preparation is classified as dangerous in accordance with directive 199945ec. Gray baby syndrome is a theoretical concern, particularly near term, but there is no clear evidence of fetal risk. The most serious adverse reaction seen with the use of chloramphenicol is reversible, dose related, bone marrow depression.